Genomic Epidemiology
Our research is dedicated to integrating genomic data with epidemiological studies to identify genetic and environmental risk factors for diseases in African populations. This powerful combination allows us to gain a comprehensive understanding of disease causation, moving beyond single-factor analyses to explore the complex interplay between inherited predispositions and environmental exposures unique to the African continent.
Africa's immense genetic diversity, coupled with its varied environments and disease burdens—ranging from persistent infectious diseases like malaria and HIV to rapidly rising non-communicable diseases (NCDs) like diabetes and cardiovascular conditions—makes this integrated approach essential.
Advancing Health in Africa Through Integrated Genomics and Epidemiology
Our research is dedicated to integrating genomic data with epidemiological studies to identify genetic and environmental risk factors for diseases in African populations. This powerful combination allows us to gain a comprehensive understanding of disease causation, moving beyond single-factor analyses to explore the complex interplay between inherited predispositions and environmental exposures unique to the African continent.
Africa's immense genetic diversity, coupled with its varied environments and disease burdens—ranging from persistent infectious diseases like malaria and HIV to rapidly rising non-communicable diseases (NCDs) like diabetes and cardiovascular conditions—makes this integrated approach essential. By analyzing large-scale genomic datasets alongside detailed epidemiological information (such as lifestyle, diet, exposure to pathogens, and geographic location), we can pinpoint specific genetic variants that confer susceptibility or protection against diseases, as well as critical environmental triggers. This allows for more precise risk stratification and the development of targeted prevention strategies tailored to the specific needs of diverse African communities.
Furthermore, a key pillar of our work involves supporting public health initiatives through the genomic surveillance of infectious diseases. This cutting-edge approach utilizes rapid genomic sequencing of pathogens to monitor their evolution, track transmission pathways, identify emerging drug resistance, and detect novel strains. For example, during outbreaks, genomic surveillance can quickly identify the source of infection and map its spread, providing crucial real-time data to public health officials in Nairobi and beyond. This allows for swift, evidence-based responses, guiding vaccination campaigns, informing public health advisories, and ensuring that control measures are as effective as possible in mitigating disease impact. By combining deep insights into genetic and environmental risk factors with dynamic pathogen surveillance, we aim to build a more resilient and responsive public health infrastructure across Africa.